| 3-5A Week 5 | Scores |
| 9/28 Acadiana (4-0) at Barbe (4-0) | Acadiana 50 Barbe 14 FINAL |
| 9/28 Comeaux (2-2) at Sam Houston (4-0) | Sam Houston 35 Comeaux 8 FINAL |
| 9/28 Lafayette (1-3) vs Sulphur (1-3) | Sulphur 21 Lafayette 14 FINAL |
| 9/28 Lagrange (0-4) vs New Iberia (0-4) | New Iberia 30 LaGrange 22 FINAL |
| 4-4A Week 5 | Scores |
| 9/28 Carencro (1-3) vs McDonogh 35 (2-2) | McDonogh 35 14 Carencro 7 FINAL |
| 9/28 Northside (2-2) at Avoyelles (1-3) | Avoyelles 66 Northside 26 FINAL |
| 9/28 Rayne (1-3) at Leesville (4-0) | Leesville 41 Rayne 26 FINAL |
| 9/28 St. Thomas More (3-1) at Franklinton (2-2) | St. Thomas More 56 Franklinton 21 FINAL |
| 9/28 Teurlings (2-2) vs Catholic Baton Rouge (3-1) | Catholic Baton Rouge 34 Teurlings 14 FINAL |
| 9/28 Westgate (2-2) at Patterson (1-3) | Westgate 47 Patterson 22 FINAL |
| 5-4A Week 5 | Scores |
| 9/28 Beau Chene (0-4) vs Vinton (2-2) | Vinton 46 Beau Chene 7 FINAL |
| 9/28 Breaux Bridge (2-2) at Natchitoches Central (2-2) | Breaux Bridge 28 Natchitoches 7 FINAL |
| 9/27 Cecilia (1-3) vs McKinley (1-3) | Cecilia 26 McKinley 0 FINAL |
| 9/28 Livonia (4-0) at Donaldsonville (3-1) | Livonia 36 Donaldsonville 0 FINAL |
| 9/28 Opelousas (3-1) vs Tara (1-3) | Opelousas 27 Tara 21 FINAL |
| 9/28 St. Martinville (4-0) vs Woodlawn Baton Rouge (1-3) | St. Martinville 42 Woodlawn BR 3 FINAL |
| 5-3A Week 5 | Scores |
| 9/28 Church Point (4-0) at Eunice (4-0) | Church Point 22 Eunice 20 FINAL |
| 9/28 Crowley (2-2) at Northwest (3-1) | Crowley 32 Northwest 28 FINAL |
| 9/28 Iota (4-0) vs Mamou (0-4) | Iota 37 Mamou 0 FINAL |
| 9/28 Pine Prairie (1-3) vs Port Barre (2-2) | Pine Prairie 27 Port Barre 0 FINAL |
| 8-3A Week 5 | Scores |
| 9/28 Abbeville (2-2) at Marksville (2-2) | Marksville 28 Abbeville 14 FINAL |
| 9/28 Berwick (1-3) at Ascension Episcopal (4-0) | Berwick 38 Ascension Episcopal 24 FINAL |
| 9/28 Erath (0-4) vs Welsh (3-1) | Welsh 41 Erath 12 FINAL |
| 9/28 Kaplan (2-2) vs Notre Dame (4-0) | Notre Dame 20 Kaplan 6 FINAL |
| 9/28 North Vermillion (3-1) at South Beauregard (1-3) | South Beauregard 35 North Vermillion 21 FINAL |
| 6-2A Week 5 | Scores |
| 9/27 Kinder (2-2) at DeQuincy (2-2) | Kinder 35 DeQuincy 6 FINAL |
| 9/28 Lake Arthur (2-1) vs East Beauregard (4-0) | Lake Arthur 48 East Beauregard 22 FINAL |
| 9/28 Ville Platte (1-2) vs Oakdale (0-4) | Oakdale 33 Ville Platte 6 FINAL |
| 7-2A Week 5 | Scores |
| 9/27 Catholic New Iberia (3-1) at Jeanerette (2-2) | Catholic New Iberia 63 Jeanerette 6 FINAL |
| 9/27 Delcambre (0-4) vs West St. Mary (0-4) | West St. Mary 44 Delcambre 12 FINAL |
| 9/28 Franklin (1-3) at Loreauville (0-4) | Franklin 28 Loreauville 0 FINAL |
| 5-1A Week 5 | Scores |
| 9/28 Catholic Point Coupee (3-1) vs Sacred Heart (3-1) | Catholic Point Coupee 23 Sacred Heart 17 FINAL |
| 9/28 North Central (1-3) vs Rosepine (4-0) | Rosepine 44 North Central 6 FINAL |
| 9/28 Slaughter (1-3) at Westminster Christian (0-4) | Slaughter 42 Westminster Christian 7 FINAL |
| 7-1A Week 5 | Scores |
| 9/27 Centerville (4-0) vs Vermillion Catholic (4-0) | Vermillion Catholic 34 Centerville 6 FINAL |
| 9/28 Central Catholic (1-2) vs Lafayette Christian (4-0) | Lafayette Christian 48 Central Catholic 0 FINAL |
| 9/28 Hanson Memorial (1-3) vs Gueydan (3-1) | Gueydan 27 Hanson Memorial 6 FINAL |
| 9/28 Highland Baptist (0-4) vs St. John (2-2) | St. John 69 Highland Baptist 12 FINAL |